摘要：Large bone defect regeneration has always been recognized as a challenging clinical problem due to the difficulty of *** treatments exhibit certain inherent disadvantages(e.g.,secondary injury,immunization,and potential infections).However,three-dimensional(3D)printing technology as an emerging field can serve as an effective approach to achieve satisfactory revascularization while making up for the above limitations.A wide variety of methods can be used to facilitate blood supply during the design of a 3D-printed ***,the scaffold structure lays a foundation for the entire printing object;any method to promote angiogenesis can be effective only if it is based on well-designed *** this review,different designs related to angiogenesis are summarized by collecting the literature from recent *** 3D-printed scaffolds are classified into four major categories and discussed in detail,from elementary porous scaffolds to the most advanced bone-like ***,structural design suggestions to achieve rapid angiogenesis are proposed by analyzing the above *** review can provide a reference for organizations or individual academics to achieve improved bone defect repair and regeneration using 3D printing.

摘要：Sensitivity analysis is used to quantify the contribution of the uncertainty of input variables to the uncertainty of systematic output *** tolerance design in manufacturing and assembly,sensitivity analysis is applied to help designers allocate tolerances ***,different sensitivity indices derived from different sensitivity analysis methods will always lead to conflicting *** is necessary to find a sensitivity index suitable for tolerance allocation to transmission mechanisms so that the sensitivity results can truly reflect the effects of tolerances on kinematic and dynamic *** this paper,a variety of sensitivity indices are investigated and compared based on hybrid ***,the hybrid simulation model of the crank-slider mechanism is ***,samples of the kinematic and dynamic responses of the mechanism with joint clearances and link length errors are obtained,and the surrogate model established using polynomial chaos expansion(PCE).Then,different sensitivity indices are calculated based on the PCE model and are further used to evaluate the effect of joint clearances and link length errors on the output *** with the tolerance-cost function,the corresponding tolerance allocation schemes are obtained based on different sensitivity analysis ***,the kinematic and dynamic responses of the mechanism adopting different tolerance allocation schemes are simulated,and the sensitivity index corresponding to the optimal response is determined as the most appropriate index.

摘要：In this study,we designed an oil-filled motor that can be used at full-ocean depths,and investigated the friction losses caused by the rotating seal and the properties of the *** direct current(DC)motor is encapsulated in an aluminum alloy housing.A rubber diaphragm is used to balance the internal and external pressures so that the motor can work on the seabed without pressure *** study the resistance caused by the rotating seal,a numerical model of the Glyd ring and the rotating shaft was *** from a rotational torque test agreed with those from numerical *** kinematic viscosity of four oils was measured at 1-25℃.Oil bath experiments in an incubator showed that the resistance from oil is highly correlated with its dynamic *** appears to be very suitable as an insulating oil for these *** working characteristics of the motor were tested in a high-pressure *** results showed that the motor needs to overcome higher oil resistance under higher pressure.A prototype of a pressure-adaptive motor was designed and applied successfully in the hadal zone at a water depth of more than 10000 m.

摘要：Biomanufacturing(BM)is a multidisciplinary area incorporating the characteristics of living organisms and engineering principles to create valuable products for various sectors,including medicine,energy,and the *** has undergone a remarkable transformation in the last two decades,entering the era of BM4.0 and becoming a pivotal driver of the sustainable ***,Japan has made significant advances in BM,contributing to its development through the creation of innovative materials,advanced processes,and interdisciplinary ***,because of certain development policies,this research has not been widely recognized on an international *** paper provides a comprehensive summary of the research progress made by renowned Japanese laboratories and researchers in biomedical materials,bio-three-dimensional(3D)printing,and biomedical applications in the last five *** unique contributions are introduced and analyzed,illuminating the distinctive approaches and breakthroughs within each ***,this review highlights the current challenges and prospects of *** viewpoints presented in this paper are intended to serve as a valuable reference for scholars studying BM in Japan.

摘要：This report provides a highlight of the third International Conference on Biomaterials,Bio-Design and Manufacturing(BDMC2023).BDMC2023,based on the journal of Bio-Design and Manufacturing(BDM)founded by zhejiang university,was successfully held in Singapore on August 6–8,2023.

摘要：Bio-manufacturing,a frontier interdisciplinary subject,is a promising field full of creative thinking and innovation[1].In order to create a platform for young scientists and students in the bio-manufacturing field to have a good chance of communication and discussion,based on the success of First Bio-Design&Manufacturing Youth Forum in 2021[2],the Second Bio-Design&Manufacturing Youth Forum chaired by the editor-in-chief Academician Huayong Yang and jointly sponsored by the journal of Bio-Design and Manufacturing,School of Mechanical Engineering,zhejiang university and the State Key Laboratory of Fluid Power and Mechatronic Systems was successfully held in Hangzhou on November 19,*** prestigious young scientists were invited to deliver a speech on their own research both onsite and online。

摘要：Owing to the inherent central information processing and resource management ability,the cloud radio access network(C-RAN)is a promising network structure for an intelligent and simplified sixth-generation(6G)wireless ***,to further enhance the capacity and coverage,more radio remote heads(RRHs)as well as high-fidelity and low-latency fronthaul links are required,which may lead to high implementation *** address this issue,we propose to exploit the intelligent reflecting surface(IRS)as an alternative way to enhance the C-RAN,which is a low-cost and energy-efficient ***,we consider the uplink transmission where multi-antenna users communicate with the baseband unit(BBU)pool through multi-antenna RRHs and multiple IRSs are deployed between the users and *** can conduct either point-to-point(P2P)compression or Wyner-Ziv coding to compress the received signals,which are then forwarded to the BBU pool through fronthaul *** investigate the joint design and optimization of user transmit beamformers,IRS passive beamformers,and fronthaul compression noise covariance matrices to maximize the uplink sum rate subject to fronthaul capacity constraints under P2P compression and Wyner-Ziv *** exploiting the Arimoto-Blahut algorithm and semi-definite relaxation(SDR),we propose a successive convex approximation approach to solve non-convex problems,and two iterative algorithms corresponding to P2P compression and Wyner-Ziv coding are *** results verify the performance gain brought about by deploying IRS in C-RAN and the superiority of the proposed joint design.

摘要：Regeneration and reconstruction of bone tissue is always a challenge for clinicians due to the uncertainty of bone repair materials in terms of long-term and efficient effects on ***,we propose a novel strategy combining benidipine,an antihypertensive drug and nanoparticles to synergistically promote the healing of bone *** and porous benidipine-loaded magnesium silicate nanoparticles were prepared and validated for their *** nanoparticles were efficiently taken up by preosteoblasts and uniformly distributed around the *** internalization into cells,the nanosystem is degraded by lysosomes,and the effect of promoting osteogenic differentiation is reflected by the continuous release of benidipine,silicon and magnesium *** results clearly evaluated that the nanoflower-like magnesium silicate delivering benidipine tends to be more appropriate for the bone regeneration in preosteoblasts,indicating that it might be a potential approach in guiding bone repair in clinical applications.

摘要：Ideal tissue engineering scaffolds need interconnected pores and high porosity to enable cell survival,migration,proliferation,and ***,obtaining a high-resolution structure is difficult with traditional one-temperature control fused deposition modeling(FDM).In this study,we propose a dual-temperature control method to improve printability.A numerical model is developed in which the viscosity is a function of temperature and shear rate to study the influence of two different temperature control *** tests are used to assess filament formation and shape fidelity,including one-dimensional filament printing,deposition at corners,fusion,and *** using dual-temperature control,the width of the deposited poly(ε-caprolactone)filament is reduced to 50μ*** comparative results of both the experimental method and numerical simulation suggest that the dual-temperature control FDM can manufacture spatially arranged constructs and presents a promising application in tissue engineering。

摘要：1 Introduction—starting at noetic science One question that has long puzzled the artificial intelligence(Al)community is:Can Al be creative?Or,can the reasoning process be creative?Starting at noetic science,this paper discusses the issues of visual knowledge representation and its potential applications to machine *** this paper,we enumerate related research on imagery-thinking-based reasoning,then focus on a special type of visual knowledge representation,i.e.,visual scene graph,and finally review the problem of visual scene graph construction and its potential applications in detail.