摘要：Touch-sensitive screens are crucial components of wearable *** such as reduced graphene oxide(rGO),carbon nanotubes(CNTs),and graphene offer promising solutions for flexible touch-sensitive ***,when stacked with flexible substrates to form multilayered capacitive touching sensors,these materials often suffer from substrate delamination in response to deformation;this is due to the materials having different Young’s modulus *** results in failure to offer accurate touch screen *** this work,we demonstrate an induced charge-based mutual capacitive touching sensor capable of high-precision touch *** is enabled by electron trapping and polarization effects related to mixed-coordinated bonding between copper nanoparticles and vertically grown graphene ***,we used an electron cyclotron resonance system to directly fabricate graphene-metal nanofilms(GMNFs)using carbon and copper,which are firmly adhered to flexible *** being subjected to 3000 bending actions,we observed almost no change in touch *** screen interaction system,which has a signal-to-noise ratio of 41.16 dB and resolution of 650 dpi,was tested using a handwritten Chinese character recognition trial and achieved an accuracy of 94.82%.Taken together,these results show the promise of touch-sensitive screens that use directly fabricated GMNFs for wearable devices.

摘要：生物材料表面的物理性质,如拓扑结构,由于其易于加工和稳定的生物作用而受到广泛关注.虽然已有许多研究报道了材料表面拓扑结构与细胞的相互作用,但由于不同研究中使用的微结构和实验环境的多样性,生物材料表面不同微结构与细胞/组织行为之间的影响关系尚未得到很好的统一评价.在本研究中,我们设计了11种图案(三角形、矩形、圆形等),这些图案包含两种类型的形貌(微坑和微柱),这样一共得到22种表面拓扑结构.我们在体外和体内对这些微结构影响细胞和组织的生物作用进行了评估.我们的研究结果表明,由连续微坑形成的凹槽微结构促进细胞迁移效果相比其他微结构更强.其中,由三角形微坑组成的凹槽在体外对细胞迁移的促进作用最强.在大鼠皮下模型中,这种三角形微坑组成的凹槽结构减少了纤维组织的包封,促进了血管的形成.

摘要：Large bone defect regeneration has always been recognized as a challenging clinical problem due to the difficulty of *** treatments exhibit certain inherent disadvantages(e.g.,secondary injury,immunization,and potential infections).However,three-dimensional(3D)printing technology as an emerging field can serve as an effective approach to achieve satisfactory revascularization while making up for the above limitations.A wide variety of methods can be used to facilitate blood supply during the design of a 3D-printed ***,the scaffold structure lays a foundation for the entire printing object;any method to promote angiogenesis can be effective only if it is based on well-designed *** this review,different designs related to angiogenesis are summarized by collecting the literature from recent *** 3D-printed scaffolds are classified into four major categories and discussed in detail,from elementary porous scaffolds to the most advanced bone-like ***,structural design suggestions to achieve rapid angiogenesis are proposed by analyzing the above *** review can provide a reference for organizations or individual academics to achieve improved bone defect repair and regeneration using 3D printing.

摘要：Regeneration and reconstruction of bone tissue is always a challenge for clinicians due to the uncertainty of bone repair materials in terms of long-term and efficient effects on ***,we propose a novel strategy combining benidipine,an antihypertensive drug and nanoparticles to synergistically promote the healing of bone *** and porous benidipine-loaded magnesium silicate nanoparticles were prepared and validated for their *** nanoparticles were efficiently taken up by preosteoblasts and uniformly distributed around the *** internalization into cells,the nanosystem is degraded by lysosomes,and the effect of promoting osteogenic differentiation is reflected by the continuous release of benidipine,silicon and magnesium *** results clearly evaluated that the nanoflower-like magnesium silicate delivering benidipine tends to be more appropriate for the bone regeneration in preosteoblasts,indicating that it might be a potential approach in guiding bone repair in clinical applications.

摘要：Although human-induced pluripotent stem cell-derived cardiomyocytes(hi PSC-CMs) have been used for disease modeling and drug discovery, clinically relevant three-dimensional(3D) functional myocardial microtissues are lacking. Here, we developed a novel ring-shaped cardiac microtissue comprised of chamber-specific tissues to achieve a geometrically non-orientable ventricular myocardial band, similar to a M?bius loop. The ring-shaped cardiac tissue was constructed of hi PSC-CMs and human cardiac fibroblasts(h CFs) through a facile cellular self-assembly approach. It exhibited basic anatomical structure,positive cardiac troponin T(c Tn T) immunostaining, regular calcium transients, and cardiac-like mechanical strength. The cardiac rings can be self-assembled and scaled up into various sizes with outstanding stability, suggesting their potential for precise therapy, pathophysiological investigation, and large-scale drug screening.

摘要：Prosthesis implantation and fat transplantation are common breast *** general,prosthesis implantation alone does not achieve a realistic enough appearance,and fat transplantation alone is difficult to achieve in the correct *** date,no reports have focused on methods of combining fat with implanted prostheses for breast *** a newly designed bionic ink(i.e.,polyether F127 diacrylate(F127DA)&poly(ethylene glycol)diacrylate(PEGDA))and projection-based three-dimensional bioprinting(PBP),we report the development of a new method for printing porous *** was used to improve the printing precision of the prosthesis by increasing the gel point of F127DA and reducing the impact of external *** compression modulus of the printed prosthesis was very close to that of prostheses currently used in clinical practice and to that of natural ***,stromal vascular fraction gel(SVF-gel),a human fat extract,was injected into the pores of the synthesized prostheses to prepare a prosthesis mixed with adipose *** were implanted subcutaneously in nude mice to observe their biological *** 14 and 28 days of observation,the prosthesis showed good biocompatibility,and adipose tissues grew well in and around the *** result shows that a porous prosthesis containing pre-placed adipose tissues is a promising breast reconstruction material.

摘要：Micro-/nano-patterns on hydrogels are widely used in cell ***,manufacturing molds with traditional lithography is time-consuming and *** addition,the excessive demolding force can easily damage patterns since biocompatible hydrogels are ultra-soft or ***,we presented a novel method for rapid and mass fabrication of cell ***-precision three-dimensional(3D)printing was used to manufacture a mold with a resolution of 2µm,and the gelatin-based hydrogel was cured by thermal–photo-crosslinking so that the low-concentration and low-substitutionrate hydrogel could be demolded *** found that pre-cooling before illumination made gelatin-based hydrogels resilient due to the partial regain of triple-helix *** this method,arbitrarily customized hydrogel patterns with a feature size of 6–80µm can be fabricated stably and at low *** cardiomyocytes were seeded on ultra-soft hydrogels with parallel groove structures,a consistent and spontaneous beating with 216 beats per minute(BPM)could be observed,approaching the natural beating rate of rat hearts(300 BPM).Overall,this work provides a general scheme for manufacturing cell patterns which has great potential for cell ethology and tissue repair.

摘要：Organ-on-a-chip systems have been increasingly recognized as attractive platforms to assess toxicity and to develop new therapeutic ***,current organ-on-a-chip platforms are limited by a“single pot”design,which inevitably requires holistic analysis and limits parallel ***,we developed a digital organ-on-a-chip by combining a microwell array with cellular microspheres,which significantly increased the parallelism over traditional organ-on-a-chip for drug *** to 127 uniform liver cancer microspheres in this digital organ-on-a-chip format served as individual analytical units,allowing for analysis with high consistency and quick *** platform displayed evident anti-cancer efficacy at a concentration of 10μM for sorafenib,and had greater alignment than the“single pot”organ-on-a-chip with a previous in vivo *** addition,this digital organ-on-a-chip demonstrated the treatment efficacy of natural killer cell-derived extracellular vesicles for liver cancer at 50μg/*** successful development of this digital organ-on-a-chip platform provides high-parallelism and a low-variability analytical tool for toxicity assessment and the exploration of new anticancer modalities,thereby accelerating the joint endeavor to combat cancer.

摘要：pH-sensitive smart polymeric nanocarriers have been under development in the field ofbiomedicine due to permeabilization the physiological barriers readily to address the limitation of conventional chemotherapeutics delivery systems of low intracellular transport and targeting *** traditional polymers kept stable under physiological neutral or acidic conditions,pH-sensitive polymeric nanocarriers underwent rapid degradation with a labile group in tumor acidic environment(around 5.0-6.0),allowing these biomaterials to achieve controlled drug release,drug pharmacokinetics improvement and antitumor biotherapeutic molecules efficiency enhancement compared with traditional *** review mainly concentrated on properties of pH-sensitive polymers for biomedical purposes to construct the smart drug delivery system based on acid liable linkers which were categorized into pH-sensitive polymeric prodrugs composed of antitumor drugs(doxorubicin and paclitaxel)bounded to the polymer via acid liable linkers and pH-sensitive copolymeric nanocarriers prepared by block copolymers containing polymer blocks linked with acid-cleavable ***,advanced platforms in biomedicine for special biotherapeutic molecules delivery were reviewed in the ***,several acid-sensitive linkages were reviewed to study the mechanism of the controlled pH-responsive drug delivery,such as hydrazone,acetal,cis-aconityl linker and β-thioether ester,as well as improvement of drug pharmacokinetics.

摘要：Mandibular defect occurs more frequently in recent years,and clinical repair operations via bone transplantation are difficult to be further improved due to some intrinsic *** engineering,which is a hot research field of biomedical engineering,provides a new direction for mandibular defect *** the basis and key part of tissue engineering,scaffolds have been widely and deeply studied in regards to the basic theory,as well as the principle of biomaterial,structure,design,and fabrication ***,little research is targeted at tissue regeneration for clinic repair *** mandibular bone has a special structure,rather than uniform and regular structure in existing studies,a methodology based on tissue engineering is proposed for mandibular defect repair in this *** steps regarding scaffold digital design,such as external shape design and internal microstructure design directly based on triangular meshes are discussed in *** analyzing the theoretical model and the measured data from the test parts fabricated by rapid prototyping,the feasibility and effectiveness of the proposed methodology are properly *** works about mechanical and biological improvements need to be done to promote its clinical application in future.